Are tetracyclines teratogenic?
Tetracycline Pregnancy Warnings Tetracycline has been assigned to pregnancy category D by the FDA. Animal studies have revealed evidence of embryotoxicity and teratogenicity, including toxic effects on skeletal formation.
What is teratogenic effect of tetracycline?
It is well known that use of a tetracycline during the second or third trimesters of pregnancy can discolour the unborn baby’s developing milk teeth and prevent the enamel from forming properly. This means that when the baby’s milk teeth come through they might be stained grey, brown or yellow.
Which antibiotics are teratogenic?
Some antibiotics are known to be teratogenic and should be avoided entirely during pregnancy. These include streptomycin and kanamycin (which may cause hearing loss) and tetracycline (which can lead to weakening, hypoplasia, and discoloration of long bones and teeth). How about other antibiotics?
Are tetracyclines contraindicated in pregnancy?
Tetracyclines are contraindicated in pregnancy because of the risk of hepatotoxicity in the mother, the potential for permanent discoloration of teeth in the fetus (yellow or brown in appearance), as well as impairment of fetal long bone growth.
What is the classification of tetracycline?
Tetracycline is in a class of medications called tetracycline antibiotics.
Can tetracycline cause miscarriage in early pregnancy?
Antibiotics and Risk for Spontaneous Abortion In a study of 182,000 pregnant women, the use of certain antibiotics during early pregnancy was linked with a higher rate of miscarriage before 20 weeks. These antibiotics included quinolones, tetracyclines, sulfonamides, metronidazole, and macrolides (except erythromycin).
Which drug is not teratogenic?
Examples of non-teratogenic agents: spermicides, acetaminophen, prenatal vitamins, using a microwave to cook food. A non-teratogenic agent is one which does not cause birth defects.
What are some examples of a teratogen?
Common teratogens include some medications, recreational drugs, tobacco products, chemicals, alcohol, certain infections, and in some cases, uncontrolled health problems in the birthing parent. Alcohol is a well-known teratogen that can cause harmful effects on the fetus after exposure at any time during pregnancy.
Why should tetracycline drugs be avoided during pregnancy and lactation?
Summary of Use during Lactation A number of reviews have stated that tetracycline is contraindicated during breastfeeding because of possible staining of infants’ dental enamel or bone deposition of tetracyclines.
Which drug is contraindicated during pregnancy due to its teratogenicity?
Teratogenic drugs and birth defects isotretinoin (an acne drug) alcohol. cocaine. high doses of vitamin A.
What are the contraindications of tetracycline?
Contraindications / Precautions
- Sulfite hypersensitivity, tartrazine dye hypersensitivity, tetracyclines hypersensitivity.
- Pregnancy.
- Children, infants, neonates.
- Breast-feeding.
- Renal disease, renal failure, renal impairment.
- Hepatic disease.
- Sunlight (UV) exposure.
- Surgery.
Can tetracycline abort early pregnancy?
Can tetracyclines cause miscarriage?
Many classes of commonly prescribed antibiotics, including macrolides, quinolones, tetracyclines and sulfonamides may be associated with an increased risk of miscarriage during the first 20 weeks of pregnancy, a Canadian research study has concluded.
What are the 5 teratogens?
Teratogenic agents include infectious agents (rubella, cytomegalovirus, varicella, herpes simplex, toxoplasma, syphilis, etc.); physical agents (ionizing agents, hyperthermia); maternal health factors (diabetes, maternal PKU); environmental chemicals (organic mercury compounds, polychlorinated biphenyl or PCB.
Why tetracycline is not given in lactating mother?
Breastfeeding. Use is not recommended since tetracyclines pass into breast milk. They may cause the nursing baby’s teeth to become discolored and may slow down the growth of the baby’s teeth and bones.
What is the most common side effect of tetracyclines?
Nausea, vomiting, diarrhea, loss of appetite, mouth sores, black hairy tongue, sore throat, dizziness, headache, or rectal discomfort may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.