What is a heterotopic ossification?
Heterotopic ossification (HO) is a diverse pathologic process, defined as the formation of extraskeletal bone in muscle and soft tissues. HO can be conceptualized as a tissue repair process gone awry and is a common complication of trauma and surgery.
What is the cause of heterotopic ossification?
Heterotopic ossification (HO) occurs when bone tissue develops in your soft tissues. Often, people get HO after an injury or major surgery. Genetic HO is rarer and more severe. In HO, you develop a bony, painful lump underneath your skin.
What causes heterotopic ossification hip?
HO occurs after other injuries, too. HO has been known to occur in cases of traumatic brain injury, stroke, poliomyelitis, myelodysplasia, carbon monoxide poisoning, spinal cord tumors, syringomyelia, tetanus, multiple sclerosis, post total hip replacements, post joint arthroplasty, and after severe burns.
How do you treat HO?
As treatment or prophylaxis for HO, either a nonsteroidal antiinflammatory drug (such as indomethacin), a diphosphonate (such as ethane-1-hydroxy-1,1-diphosphate), or local radiation therapy is recommended. Before therapy begins, bone scanning may be requested to confirm the diagnosis of HO.
What causes HO?
Heterotopic ossification (HO) is the presence of bone in soft tissue where bone normally does not exist. The acquired form of HO most frequently is seen with either musculoskeletal trauma, spinal cord injury, or central nervous system injury.
How do you remove heterotopic ossification?
In the case of heterotopic ossification, the only effective treatment is excision, also called resection. Dr. Nwachukwu will often delay surgical excision for 5-6 months following the initial hip trauma and/or inciting surgery, allowing the bone growth to mature and for a distinct fibrous capsule to develop.
Is there a cure for heterotopic ossification?
The two main treatments available are radiation therapy and NSAIDs. Bisphosphonates have been used in the past, but their use has been discontinued as they only postpone ossification until treatment is stopped.
What are the 3 stages of ossification?
The process of bone formation is called osteogenesis or ossification. After progenitor cells form osteoblastic lines, they proceed with three stages of development of cell differentiation, called proliferation, maturation of matrix, and mineralization.
Which bones ossify first?
The clavicle is the first bone to ossify in the devel- oping embryo. At approximately 5 weeks of gesta- tion, primary ossification of the clavicle proceeds by membranous ossification of two centers with no prior cartilaginous anlage.
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