How long does alfaxalone last in cats?
This formulation has a shelf life of 28 days after first use. It is approved for IV administration to induce and maintain general anesthesia in dogs and cats; however, it is also used via the IM route for induction and sedation (off label). Alfaxalone is less painful than ketamine when injected via the IM route.
Can you reverse alfaxalone?
There is no reversal agent for alfaxalone; however, other drugs administered that cause cardiorespiratory depression should be antagonised if possible.
What is Alfaxan used for in cats?
Alfaxalone, also known as alphaxolone or alphaxalone and used under the trade name Alfaxan®, is a neuroactive steroid and general anesthetic drug used in dogs and cats. It can be used as an induction agent or for general anesthesia.
How long does Alfaxan last?
Once ALFAXAN has been opened, vial contents should be drawn into sterile syringes; each syringe should be prepared for single patient use only. Unused product should be discarded within 6 hours….Dogs.
| Dose and Duration | Preanesthetized dogs | Unpreanesthetized dogs |
|---|---|---|
| Mean duration of anesthesia | 6 – 8 minutes | 6 – 8 minutes |
How long does Alfaxan take to work?
6-12 minutes
Onset of action is rapid with mean times to lateral recumbency of 6-12 minutes (Ribas et al., 2014; Granfone et al., 2017; Reader et al., 2018; Rodrigo-Mocholi et al., 2018) and peak sedation by approximately 15 minutes post administration (Cremer & Ricco, 2018).
Is Alfaxan safer than propofol?
Side Effects. Alfaxalone and propofol are equally safe. Both drugs are known to cause post-induction apnoea, which is a transient suppression of respiration. This is routinely managed by manual ventilation (‘bagging’) for 30 seconds to 2 minutes after induction.
Can alfaxalone and propofol be used together?
In order to prevent rough recoveries, alfaxalone should not be used as a solo agent. The same could be said for ketamine, propofol and inhalant agents. Smoother recoveries are expected when anesthetic agents are used in conjunction with sedative/analgesic medications.
Is Alfaxan a sedative?
Alfaxalone administered via the intramuscular route provides rapid, dose-dependent sedation or general anaesthesia. Combining with (dex)medetomidine and an opioid will reduce dose requirements, and therefore injection volume, and will aid a smooth recovery.
Is alfaxalone a steroid?
4.4. Alfaxalone (Alfaxan, Vetoquinol) is a neurologically active steroid compound that induces general anaesthesia. Alfaxalone exerts its action by binding to GABA receptors on the neuronal cell surface, affecting cell membrane chloride ion transport. It has negligible analgesic properties at therapeutic doses.
Is Alfaxan controlled?
Alfaxalone is classified by the Drug Enforcement Agency as a Schedule IV controlled substance.
Can you mix butorphanol and alfaxalone?
Alfaxan® can be safely combined with premedicants (xylazine, (dex)medetomidine, acepromazine, midazolam), opioids (morphine, methadone, hydromorphone, butorphanol, nalbuphine, buprenorphine, fentanyl), and NSAIDs.
What is the difference between Alfaxan and Alfaxan multidose?
Alfaxan Multidose is bioequivalent to unpreserved Alfaxan, however the preserved system reduces risk of microbial contamination, prolonging the shelf life after the first use to 28 days.
Why is alfaxalone controlled?
As such, the DEA is scheduling alfaxalone as a controlled substance under the CSA. (3) Abuse of 5[alpha]-pregnan-3[alpha]-ol-11,20-dione (alfaxalone) may lead to limited physical dependence or psychological dependence relative to the drugs or other substances in schedule III.
Is alfaxalone a barbiturate?
Alphaxalone (Figure 2) is a steroid anesthetic, a neurosteroid, used for short-term anesthesia that is similar in its effects to barbiturates but has a wider margin of safety than barbiturates and produces less apnea on induction.
Is alfaxalone an option for cats with premedication or sedation?
IM alfaxalone may also be an option in cats that have received premedication or sedation but who are still difficult to handle prior to IV cannulation. An article discussing alpha-2 agonists can be accessed here.
ALFAXAN is indicated for the induction and maintenance of anesthesia and for induction of anesthesia followed by maintenance with an inhalant anesthetic, in cats and dogs. Administer by intravenous injection only.
Is alfaxalone an alternative to dexmedetomidine for cats undergoing blood donation?
The combination of alfaxalone + butorphanol IM was a suitable alternative to dexmedetomidine + butorphanol for cats undergoing blood donation and provided a stress-free, efficient sedation with no apparent negative side effects. Ribas T., Bublot I., Junot S., Beaufrere H., Rannou B., Gagniere P., Cadore J.L. & Parlaut R. (2014).
What is alfaxalone used for in dogs?
Alfaxalone is a neuroactive steroid that is approved for use as an injectable anesthetic agent in dogs and cats. Alfaxalone can be used for sedation, induction of anesthesia, and for total intravenous anesthesia (TIVA). Administration of alfaxalone can provide muscle relaxation, chemical restraint, and/or general anesthesia.