What is the normal range of amyloid A?
Reference ranges SAA 10 – 25 mg/L: amyloid deposits stable in most patients- further monitoring without changes in therapy may be appropriate. SAA >50 mg/L: amyloid deposits accumulate in most patients, and more intensive or alternative treatment should be considered.
What is a serum amyloid test?
Serum amyloid A (SAA) is an early and sensitive blood biomarker for tissue injury and inflammation and has been indicated in many inflammatory diseases. The level of SAA circulating in the blood is known to increase dramatically in response to tissue damage or inflammation, classifying it as an acute phase protein.
What is amyloidosis type AA?
AA amyloidosis (previously known as secondary [AA] amyloidosis) is a disorder characterized by the extracellular tissue deposition of fibrils that are composed of fragments of and/or intact serum amyloid A protein (SAA), a hepatic acute phase reactant.
How do you read CRP results?
CRP is measured in milligrams per liter (mg/L). Results for a standard CRP test are usually given as follows: Normal: Less than 10 mg/L. High: Equal to or greater than 10 mg/L.
What is a high SAA in horses?
A commonly accepted reference interval for SAA concentration in horses is 0 to 20 mg/L,15 with most reports finding normal horses have SAA values at or lower than 12 mg/L.6 , 8 , 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30 Several studies have examined the utility of SAA for discriminating between horses …
Can AA amyloidosis be cured?
Amyloidosis is a “protein misfolding disorder.” Normally, proteins in the bloodstream are removed and/or recycled once they have completed their job. In amyloidosis, however, a protein can change shape (or “misfold”) and can no longer be cleared.
What is a normal SAA levels in horses?
SAA concentrations in the blood of healthy horses have generally been reported to range from <0.5 to 20 mg/L 4, 5, 11, 12. This wide range reflects individual features of the immune response and probably also the methods of measurement.