What is micafungin used for?
Micafungin injection is used to help the body overcome serious fungus infections, such as candidemia, acute disseminated candidiasis, candida peritonitis and abscess without meningoencephalitis or ocular dissemination, and esophageal candidiasis.
What is fungal prophylaxis?
Antifungal prophylaxis is regularly used during treatment of patients with some cancers, as subgroups with high rates of invasive fungal infections are readily identified; for these patients, prophylaxis has been shown to be of value. High-risk liver transplant recipients also benefit from antifungal prophylaxis.
Does micafungin treat Aspergillus?
Micafungin is a relatively broad-spectrum antifungal agent with in vitro activity against Candida and Aspergillus species, as well as the mycelial forms of dimorphic fungi.
What kind of drug is micafungin?
USES: This medication is used to treat a variety of fungal infections. It is also used to prevent fungal infections in patients who are having a stem cell transplant. Micafungin belongs to a class of drugs known as echinocandins. It works by stopping the growth of fungi.
Is micafungin an antibiotic?
Mycamine (micafungin sodium) is an antifungal medication used to treat infections caused by the Candida fungus, and is also used to prevent Candida fungal infections in stem cell transplant patients.
What are the side effects of micafungin?
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- Black, tarry, stools.
- decreased frequency or amount of urine.
- fast, pounding, or irregular heartbeat or pulse.
- fever or chills.
- increased thirst.
- nausea or vomiting.
- swelling of the face, fingers, or lower legs.
- ulcers, sores, or white spots in the mouth.
When do you start antifungal in ICU?
The most recent clinical practice guideline for the management of candidiasis by the Infection Disease Society of America (IDSA) stated that empiric antifungal treatment with an echinocandin should be considered in critically ill patients with risk factors and no other cause of fever, whereas it should be started as …
Is voriconazole an antibiotic?
Voriconazole is used to treat a variety of fungal infections. It belongs to a class of drugs known as azole antifungals. It works by stopping the growth of fungi.
Does micafungin treat mold?
The three major classes of modern antifungals used in the treatment of mold infections consist of: the triazole antifungals (posaconazole, voriconazole), the echinocandins (caspofungin, micafungin, anidulafungin) and AMB-based therapy.
What is the treatment for Aspergillus?
Antifungal medications. These drugs are the standard treatment for invasive pulmonary aspergillosis. The most effective treatment is a newer antifungal drug, voriconazole (Vfend). Amphotericin B is another option. All antifungal drugs can have serious side effects, including kidney and liver damage.
What is micafungin made from?
Micafungin is a semi-synthetic echinocandin derived from a natural product of the fungus Coleophama empedri with potent antifungal activity.
What is the cost of micafungin?
The cost for micafungin intravenous powder for injection 100 mg is around $162 for a supply of 1 powder for injection, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
Can you get a fungal infection from a ventilator?
Long-term mechanical ventilation in an Intensive Care Unit (ICU) exposes the patient to fungal colonization and invasive fungal disease due to the presence of indwelling catheters, administration of broad-spectrum antibiotics, and intravenous corticosteroids.
How do you treat fungal infection in ICU?
Antifungal drugs for the treatment of candidiasis include polyenes (amphotericin B deoxycholate, liposomal amphotericin B), triazoles (fluconazole, itraconazole, voriconazole, posaconazole), echinocandins (caspofungin, anidulafungin, micafungin) and flucytosine (administered mostly by oral formulation; however it is …
How long is voriconazole treatment?
In a clinical study of IA, the median duration of intravenous VFEND therapy was 10 days (range 2 to 85 days). The median duration of oral VFEND therapy was 76 days (range 2 to 232 days) (14.1).
What is Aspergillus?
Aspergillosis is a disease caused by Aspergillus, a common mold (a type of fungus) that lives indoors and outdoors. Most people breathe in Aspergillus spores every day without getting sick.
What fungus is in micafungin?
It is water-soluble and is semi-synthesized from the acylated cyclic hexapeptide FR901379, a natural product from the fungus Coleophoma empetri F-11899, through enzymatic deacylation of FR901379, followed by chemical reacylation with the optimized N-acyl side chain.
Is micafungin oral?
Mycamine is a sterile, lyophilized product for intravenous (IV) infusion that contains micafungin sodium. Micafungin sodium is a semisynthetic lipopeptide (echinocandin) synthesized by a chemical modification of a fermentation product of Coleophoma empetri F-11899.
What is the role of micafungin in the treatment of aspergillosis?
Invasive aspergillosis is a major cause of morbidity and mortality in immunocompromised patients, particularly those with neutropenia and those undergoing bone marrow or stem cell transplants. Micafungin is an echinocandin antifungal drug with activity against all major Candida spp. Currently, micaf …
What is the role of antifungal prophylaxis in the treatment of fungal infections?
It should be emphasized that antifungal prophylaxis will remain a standard approach in patients at high risk for invasive fungal infections while meticulous clinical judgement and treatment of febrile neutropenic episodes remain necessary.
What is micafungin?
Micafungin, a new echinocandin, inhibits fungal cell wall β-glucan synthesis, with potent activity against most species of Candida and Aspergillus.
Is Caspofungin a first-line treatment for invasive aspergillosis?
Echinocandins are approved for 2nd-line treatment of invasive Aspergillosis being refractory or intolerant against 1st-line drugs [ 42 ]. A small open label Phase II study (n = 61) evaluated caspofungin as first-line therapy for invasive aspergillosis in hematological diseases with 85% of patients being neutropenic at enrolment.