What is microcrystalline cellulose used for in tablets?
It is used as a binder/diluent in oral tablet and capsule formulations including both wet granulation and direct compression processes. It also has some lubricant and disintegrant properties which is useful in direct tableting.
What is the formulation of a tablet?
A tablet formulation typically comprises one or more active substance(s) and other excipients that are required to enable the pharmacokinetic and mechanical properties of the final dosage form. These excipients are primarily diluents or fillers, binders, disintegrants and lubricants.
What drugs have microcrystalline cellulose?
Top Medications with this Excipient
- Acetaminophen and Hydrocodone Bitartrate 325 mg / 5 mg.
- Acetaminophen and Hydrocodone Bitartrate 325 mg / 10 mg.
- Acetaminophen and Hydrocodone Bitartrate 325 mg / 7.5 mg.
- Acetaminophen and Hydrocodone Bitartrate 325 mg / 10 mg.
- Acetaminophen and Oxycodone Hydrochloride 325 mg / 10 mg.
How does microcrystalline cellulose MCC is made?
MCC is made from high-grade, purified wood cellulose. Hydrolysis is used to remove cellulose until the microcrystalline form remains. With its amorphous cellulose portions removed, it becomes an inert, white, free-flowing powder.
What is PH in microcrystalline cellulose?
Microcrystalline Cellulose PH 101/102/112 BP/EP/USP/JP (MCC), 25Kg. ₹ 180/ Kg Get Latest Price. Grade Type. PH 101/102/112 BP/EP/USP/JP.
What is microcrystalline cellulose soluble in?
Microcrystalline cellulose
| SYNONYMS | Cellulose gel, INS No. 460 |
|---|---|
| FUNCTIONAL USES | Emulsifier, stabilizer, anticaking and dispersing agent |
| CHARACTERISTICS | |
| IDENTIFICATION | |
| Solubility | Insoluble in water, ethanol, ether and dilute mineral acids. Slightly soluble in sodium hydroxide solution |
What is the tablet composition?
Tablets may be defined as the solid unit dosage form of medicament or medicaments with suitable excipients. It comprises a mixture of active substances and excipients, usually in powder form, pressed or compacted from a powder into a solid dose.
What are the additives and components of tablets?
Table 1 Common excipients used in tablets
| Excipient | Examples |
|---|---|
| Disintegrants | Compounds which swell or dissolve in water e.g. starch, cellulose derivatives and alginates, crospovidone |
| Glidants | Colloidal anhydrous silicon and other silica compounds |
| Lubricants | Stearic acid and its salts (e.g. magnesium stearate) |
What is another name for microcrystalline cellulose?
Cellulose, microcrystalline
| PubChem CID | 14055602 |
|---|---|
| Molecular Formula | C14H26O11 |
| Synonyms | Cellulose, microcrystalline 2-[4,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxy-6-(hydroxymethyl)-5-methoxyoxane-3,4-diol Cellulose gel SCHEMBL825024 CHEBI:167997 More… |
| Molecular Weight | 370.35 |
| Dates | Modify 2022-06-11 Create 2007-02-09 |
What is microcrystalline structure?
A microcrystalline material is a crystallized substance or rock that contains small crystals visible only through microscopic examination.
How do you dissolve microcrystalline cellulose?
Discussion. Micro-crystalline cellulose can be dissolved in NaOH/water with 7–10% of NaOH below 0 °C. DSC experiments reveal that the addition of Avicel cellulose does not change either the temperature of the NaOH eutectic mixture or the temperature of melting ice.
What are the different types of tablet coating?
There are three main processes for tablet coating: sugar coating, film coating, and enteric coating.
Which excipients are used in tablet formulation?
Which additives are used in the tablet preparation?
When making tablets, additives such as plasticizers, lubricants, disintegrants, binders, and fillers, as well as coating agents, stabilizers, emulsifiers, and viscosity enhancers can be added to the pharmaceutical formulations [114,115].
What is the chemical formula for microcrystalline cellulose?
Cellulose, microcrystalline
| PubChem CID | 14055602 |
|---|---|
| Molecular Formula | C14H26O11 |
| Synonyms | Cellulose, microcrystalline 2-[4,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxy-6-(hydroxymethyl)-5-methoxyoxane-3,4-diol Cellulose gel SCHEMBL825024 CHEBI:167997 More… |
| Molecular Weight | 370.35 |
| Dates | Modify 2022-05-28 Create 2007-02-09 |
What are the two types of tablets?
There are different types of tablets: Chewable tablets dissolve and are absorbed rapidly in the stomach, offering a quick onset of action. They may come in different flavors. Orally disintegrating tablets dissolve on the tongue.
What is the classification of tablets?
Hence, tablets can be broadly classified as compressed tablets and moulded tablets. Compressed tablets can be further classified as directly compressible tablets, chewable tablets and tablet triturates etc.
What are four types of pharmaceutical tablet coatings?
Different types of tablets need different coating according to the nature and properties of the tablets….
- Sugar Coated Tablets.
- Film Coated Tablets.
- Gelatin Coated Tablets.
- Enteric Coated Tablets.
- Compression Coating Tablets.
- Other Types.
Which material is used in polishing of tablets in sugar coating?
The final step in the sugar coating process is a polishing step. This is carried out to impart a shiny distinctive appearance to the tablet. An application of wax such as carnuba wax, candelila wax, beeswax and hard paraffin is used to polish the tablets inside a polishing pan.
Why microcrystalline cellulose tablets?
The development of microcrystalline cellulose has made available to the pharmaceutical industry an extremely valuable tableting agent. It was found that tablets of plain microcrystalline cellulose will tend to soften and swell when exposed to humid conditions, but the effect is reversed upon the removal of increased humidities.
What is the difference between microcrystalline cellulose and alpha cellulose?
Cellulose is a linear polymer of glucose. Based on solubility in alkaline, cellulose is divided into three groups which are alpha, beta, and gamma celluloses. Microcrystalline cellulose (MCC) is a purified, partially depolymerized cellulose having the formula (C 6 H 10 O 5) n. It is prepared by treating alpha cellulose with mineral acids (type Ib).
What is the role of MCC in the formulation of tablets?
Recently, MCC has been widely used in the formulation of multiparticulate and matrix tablet dosage forms for sustained release drug delivery system. In general, hydrophilic polymers in matrix tablet formulation are included to form a viscous, gelling layer which can retard water penetration and acts as a barrier to drug release.
Does humidity affect cellulose tablets?
It was found that tablets of plain microcrystalline cellulose will tend to soften and swell when exposed to humid conditions, but the effect is reversed upon the removal of increased humidities. Elevated temperatures have no effect on these tablets.
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