What WS 5570?
Objective: WS(®) 5570 is a Hypericum (St. John’s wort) dry extract that is available as a medicinal product in coated tablets and has a marketing authorisation for the acute treatment of mild to moderate major depression in Germany.
How much hypericin is in St John’s wort?
John’s wort can be obtained in many forms: capsules, tablets, tinctures, teas, and oil-based skin lotions. Chopped or powdered forms of the dried herb are also available. Most products are standardized to contain 0.3% hypericin.
What is hyperforin?
Hyperforin has been shown to inhibit, like conventional antidepressants, the neuronal uptake of serotonin, norepinephrine and dopamine. However, hyperforin inhibits also the uptake of gamma-aminobutyric acid (GABA) and L-glutamate.
What does St John’s wort do to dopamine?
Hypericin found in St. John’s wort is able to cross the blood-brain barrier and increase levels of dopamine. Dopamine plays a critical role in regulating physical behavior, movement, and healthy emotions. It is a chemical hormone and one of our main neurotransmitters in the brain.
What is hyperforin and hypericin?
Hypericin has shown antiviral activity and is a potent natural photosensitizer that has been used in photodynamic therapy against cancer and against HIV in stored blood. Hyperforin was found to activate a particular receptor in the liver that induces the production of an enzyme used for the metabolism of medications.
How much Hyperforin is in St John’s wort?
It contains 5-6% hyperforin and 0.12-0.28% hypericin (Lecrubier et al.
How does hypericin work?
Hypericin is believed to act as an antibiotic, antiviral and non-specific kinase inhibitor. Hypericin may inhibit the action of the enzyme dopamine β-hydroxylase, leading to increased dopamine levels, although thus possibly decreasing norepinephrine and epinephrine.
What does Saint John’s wort do?
It contains many chemicals that act on messengers in the brain that regulate mood. People most commonly use St. John’s wort for depression and mood disorders. There is some strong scientific evidence that it is effective for mild to moderate depression.
Can St John’s wort cause anxiety?
Side effects. At recommended doses, St. John’s wort generally does not cause side effects. Uncommon side effects of St. John’s wort include anxiety, dry mouth, sensitivity to sunlight, dizziness, stomach upset, headache, sexual problems, and fatigue.
What supplements should not be taken with St John’s wort?
Taking St. John’s wort can weaken many prescription medicines, such as:
- Antidepressants.
- Birth control pills.
- Cyclosporine, used to prevent the body from rejecting transplanted organs.
- Digoxin, a heart medication.
- Oxycodone, a pain medicine.
- Some HIV drugs, including indinavir.
- Some cancer medications, including irinotecan.
Can you take multivitamins with St John Wort?
John’s wort can also interact with other herbs and supplements. You should avoid taking any nutritional supplement or remedy that can raise serotonin, such as 5-hydroxytryptophan (5-HTP), L-tryptophan, or SAMe, if you are taking St. John’s wort.