Can gefitinib cure lung cancer?
For non-small cell lung cancer (NSCLC) harboring activating EGFR mutations, tyrosine kinase inhibitors (TKIs) such as gefitinib are remarkably effective , and no cured case of advanced NSCLC has been reported yet. Here, we now report the first case of EGFR-mutated lung adenocarcinoma cured with gefitinib.
Is gefitinib a chemotherapy?
The use of cytotoxic chemotherapy is associated with a response rate of 20 to 35% and a median survival time of 10 to 12 months among patients with advanced non–small-cell lung cancer. Gefitinib is an orally administered tyrosine kinase inhibitor of the epidermal growth factor receptor (EGFR).
How gefitinib works?
Gefitinib (Iressa) belongs to a class of drugs known as tyrosine kinase inhibitors. It works by blocking the function of a protein called the epidermal growth factor receptor (EGFR). The EGFR is found on the surface of many cancer cells as well as normal cells.
How long can you take Gefitinib?
The chemotherapy used is a relatively standard regimen of infusions every 3 weeks for four cycles — or 12 weeks of therapy — whereas gefitinib is a daily pill they take for 2 years.
What are the side effects of Gefitinib?
- Abdominal or stomach pain or tenderness.
- clay colored stools.
- decreased appetite.
- diarrhea, severe.
- itching or skin rash.
- nausea and vomiting.
- swelling of the feet or lower legs.
- yellow eyes or skin.
When is Gefitinib used?
Gefitinib is used to treat metastatic (cancer that has already spread) non-small cell lung cancer in patients who have certain types of abnormal epidermal growth factor (EGFR) genes, and did not receive cancer medicines in the past. Your doctor will perform a test before you take this medicine.
What type of drug is Gefitinib?
Gefitinib is in a class of medications called kinase inhibitors. It works by blocking the action of a certain naturally occurring substance that may be needed to help cancer cells multiply.
What is gefitinib (100 mg/kg)?
Growth inhibition assay GI50 23409107 In vivo Gefitinib (100 mg/kg) improves the anti-tumor effect of radiotherapy in LoVo tumor xenografts.
Does Selleck test the solubility of all compounds in-house?
*Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. Chemical Information
What is the ZD code for gefitinib?
Gefitinib (ZD1839) Catalog No.S1025 Synonyms: Iressa For research use only. Gefitinib (ZD-1839, Iressa) is an EGFRinhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50of 37 nM, 37nM, 26 nM and 57 nM, respectively.
What is in vivo gefitinib used for?
GI50 23409107 In vivo Gefitinib (100 mg/kg) improves the anti-tumor effect of radiotherapy in LoVo tumor xenografts.