Does bendamustine require a central line?
Each treatment takes between 30 and 60 minutes. You can have it through a thin short tube (a cannula) that goes into a vein in your arm each time you have treatment. You can also have it through a long line: a central line, a PICC line or a portacath.
How do you infuse bendamustine?
For patients with indolent NHL, bendamustine is administered as a 60-minute IV infusion on days 1 and 2 of a 21-day cycle for up to 8 cycles. The recommended dose is 120 mg/m2. A patient’s dose of bendamustine is placed in a 500-mL infusion bag of 0.9% Sodium Chloride Injection, USP (normal saline).
Does bendamustine lower your immune system?
Bendamustine can severely impair T-cell immunity against cytomegalovirus.
Can you give bendamustine peripherally?
On cycle 2 of day 1, bendamustine and rituximab were administered through a peripheral intravenous line inserted into the patient’s right forearm.
How is bendamustine and rituximab administered?
Bendamustine + Rituximab is usually given in an outpatient infusion center, allowing the person to go home afterwards. On occasion, it may be given in the hospital if someone is too sick for outpatient treatment. Bendamustine + Rituximab is repeated every 28 days. This is known as one Cycle.
What is the nadir for bendamustine?
Leukocytes (neutrophils and lymphocytes) and platelets typically reach nadir 14–20 days after bendamustine infusion, with recovery expected within 3–5 weeks19. In addition, the frequency of neutropenia tends to increase after cycle 3 and is generally higher in patients more than 65 years of age.
Does bendamustine cause fatigue?
Contact your doctor right away if you have depressed or indented skin, blue-green to black skin discoloration, or pain, redness, or peeling of the skin at the injection site. Bendamustine may cause some people to feel unusually tired or weak.
How effective is bendamustine and rituximab?
Based on the willingness-to-pay threshold of $50,000 per QALY, bendamustine plus rituximab was the more cost-effective strategy than R-CHOP 66% of the time in follicular lymphoma, 82% in mantle-cell lymphoma, 64% in marginal zone lymphoma, and 86% in lymphoplasmacytic lymphoma.
What should I know about bendamustine before taking it?
Bendamustine can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests. If you’ve ever had hepatitis B, using bendamustine can cause this virus to become active or get worse.
What is bendamustine made out of?
It was originally made from nitrogen mustard. Bendamustine has been used both as sole therapy and in combination with other agents including etoposide, fludarabine, mitoxantrone, methotrexate, prednisone, rituximab, vincristine and 90 Y- ibritumomab tiuxetan.
How much does it cost for a vial of bendamustine?
Bendamustine was approved for medical use in the United States in 2008. It is on the World Health Organization’s List of Essential Medicines, the safest and most effective medicines needed in a health system. The cost in the United Kingdom for the NHS is about 275.81 pounds per 100 mg vial.
What are the preventive measures for bendamustine hydrochloride (HCl) toxicity?
Preventive measures include vigorous hydration and close monitoring of blood chemistry, particularly potassium and uric acid levels. Allopurinol has also been used during the beginning of bendamustine HCl therapy. However, there may be an increased risk of severe skin toxicity when bendamustine HCl and allopurinol are administered concomitantly.