How is dengue fever diagnosed?
If an infection is suspected, you will get a blood test to check for the dengue virus. During a blood test, a health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial.
Which test is done for the diagnosis of dengue before 5 days?
Before day 5 of illness, during the febrile period, dengue infections may be diagnosed by virus isolation in cell culture, by detection of viral RNA by nucleic acid amplification tests (NAAT), or by detection of viral antigens by ELISA or rapid tests.
How does CBC detect dengue?
The clinical presentation of dengue patients is acute febrile illness with no localizing signs and symptoms which may mimic other infections. Therefore the laboratory tests such as a complete blood count (CBC), serological test or blood culture need to be used to differential and confirm the diagnosis.
What is CBC test for dengue?
Complete blood count (CBC)—to look for low platelet count typical of the later stages of the illness and to detect the decrease in hemoglobin, hematocrit, and red blood cell (RBC) count (evidence of anemia) that would occur with blood loss associated with severe dengue fever.
What is dengue IgG and IgM?
Dengue Antigen NS1, IgG and IgM test detects the non-structural protein component (NS1) of the dengue virus and the antibodies (IgG & IgM) produced by the body in response to the infection. NS1 and IgM is secreted into the blood during dengue infection and are detectable within 3-4 days of illness.
What is the WBC count in dengue?
Dengue fever is characterized by leucopenia (White Blood Cells (WBC) < 5000 cells/mm3), thrombocytopenia (< 150,000 cells/mm3), rising haematocrit (5–10%) and there should be no evidence of plasma leakage [10].
What is dengue IgG and IgM test?
Positive IgM and IgG tests for dengue antibodies detected in an initial blood sample mean that it is likely that the person became infected with dengue virus within recent weeks. IgM antibody tests can be positive if a person has been infected with a similar virus, such as chikungunya (called cross-reaction).
What if IgG is positive and IgM is negative?
The positive IgM plus negative IgG (IgM+ plus IgG-) results showed that 38% of those patients had a recent primary dengue infection, while the positive IgG plus either positive or negative IgM (IgG+ plus IgM+/-) results indicated that 62% had dengue for at least a second time (recent secondary infections).
What CRP test indicates?
Your doctor might order a CRP test to:
- Check for inflammation due to an infection.
- Help diagnose a chronic inflammatory disease, such as rheumatoid arthritis or lupus.
- Determine your risk of heart disease.
- Evaluate your risk of a second heart attack.
Can CBC detect dengue?
What is dengue IgM and IgG?
What is normal CRP level?
CRP is measured in milligrams per liter (mg/L). Results for a standard CRP test are usually given as follows: Normal: Less than 10 mg/L. High: Equal to or greater than 10 mg/L.
What happens if CRP is high?
A high level of CRP in the blood can be a marker of inflammation. A wide variety of conditions can cause it, from an infection to cancer. High CRP levels can also indicate that there’s inflammation in the arteries of the heart, which can mean a higher risk of heart attack.
What is NS1 positive?
A positive NS1 test result confirms dengue virus infection without providing serotype information. A negative NS1 test result does not rule out infection. People with negative NS1 results should be tested for the presence of dengue IgM antibodies to determine possible recent dengue exposure.
What is CBC CRP test?
A c-reactive protein test measures the level of c-reactive protein (CRP) in your blood. CRP is a protein made by your liver. It’s sent into your bloodstream in response to inflammation. Inflammation is your body’s way of protecting your tissues if you’ve been injured or have an infection.