What are the chemical properties of propofol?

What are the chemical properties of propofol?

The action of propofol involves a positive modulation of the inhibitory function of the neurotransmitter gama-aminobutyric acid (GABA) through GABA-A receptors….Structure for T3D2900: Propofol.

Property Value
Melting Point 18°C
Boiling Point 256°C
Solubility 124 mg/L
LogP 3.79

How is propofol made?

The solution consists of soybean oil, fats purified from egg yolks, and glycerol. Allergic reactions occur, although propofol is generally considered safe for people with egg allergies because people are usually allergic to the proteins in eggs, not the fat.

What is the pharmacokinetics of propofol?

Elimination and Excretion After metabolism, 88% of propofol is excreted within 5 days in the urine. Less than 0.3% of administered propofol is excreted unchanged [33]. The phenolic metabolites rarely (< 1% of patients) result in green discolouration of the urine [44]. Propofol is also excreted through exhalation.

What is propofol chemical formula?

C12H18OPropofol / Formula

What is chemical name of propofol?

Propofol | C12H18O – PubChem.

Does propofol have a benzene ring?

Its lone ionizable functional group, the hydroxyl, has a pKaof 11, which renders it unsuitable for forming salts in solution. 18The remaining portion of the molecule, the benzene ring and isopropyl side groups, are highly lipophilic. The result is a molecule with a poor water miscibility (150 μg/l).

What is the chemical name of propofol?

What plant does propofol come from?

Potent anesthetic: The isopropyl side groups (blue) of propofol’s chemical structure (left) are essential for the anesthetic activity and advantageous side effect profile of the drug. The soybean-derived formulation is a white liquid (right), which has inspired its nickname, Milk of Amnesia.

Where does propofol metabolized?

Propofol undergoes rapid and extensive metabolism to water-soluble inactive metabolites. The liver is the major metabolic site, but extrahepatic clearance of propofol has also been suggested since systemic propofol clearance exceeds hepatic blood flow [60, 61].

What is propofol mixed with?

Propofol 10 mg/ml should only be mixed with the following products: glucose 50 mg/ml (5%) solution for injection, sodium chloride 9 mg/ml (0.9%) solution for injection or sodium chloride 1.8 mg/ml (0.18%) and glucose 40 mg/ml (4%) solution for injection, and preservative-free lidocaine 10 mg/ml (1%) solution for …

What does propofol do to GABA receptors?

Propofol decreases the rate of dissociation of the GABA from the receptor, thereby increasing the duration of the GABA-activated opening of the chloride channel with resulting hyperpolarization of cell membranes.

Where does propofol bind on GABA?

While the presence, or isoform, of the α, γ and δ subunits have all been shown to affect propofol modulation of the GABAA receptor5–8, it seems likely that the propofol binding site involves the β subunit.

What classification is propofol?

Propofol is a prescription medication used for sedation and anesthesia. Propofol belongs to a group of drugs called general anesthetics.

Is propofol an acid or base?

Pharmacokinetics. Propofol is a 2,6-diisopropylphenol and is a lipophillic weak acid (pKa=11) (Table 1). It is very insoluble in water, so is formulated as 1% aqueous solution (10 mg ml−1) in an oil-in-water emulsion containing soya bean oil, glycerol, and egg lecithin.

Is propofol a phenol?

Propofol Chemistry Propofol is a unique compound compared to the other intravenous anesthetics. It is a simple phenol substituted with two isopropyl groups in each of the positions adjacent to the hydroxyl group, the ortho positions (fig. 1).

Why is propofol an emulsion?

Propofol is formulated as an oil-in-water emulsion because of its low water solubility. Like other phenolic compounds, propofol is a membrane irritant [6]. The pain on injection has been linked to the free propofol drug concentration, or the amount of drug freely dissolved in blood [7, 8].

Does propofol have metabolites?

What does Propofol do to GABA receptors?

What is the mechanism of action of propofol?

Formulated for intravenous induction of sedation and hypnosis during anesthesia, propofol facilitates inhibitory neurotransmission mediated by gamma-aminobutyric acid (GABA). This agent is associated with minimal respiratory depression and has a short half-life with a duration of action of 2 to 10 minutes.

Who invented propofol?

John B. Glen, a British veterinarian and researcher at Imperial Chemical Industries (ICI) spent 13 years developing propofol, an effort which led to the awarding to him of the prestigious 2018 Lasker Award for clinical research.

What is the molecular formula for propofol?

Propofol PubChem CID 4943 Structure Find Similar Structures Chemical Safety Laboratory Chemical Safety Summary (LCSS Molecular Formula C12H18O Synonyms propofol 2,6-DIISOPROPYLPHENOL 2078-54-8

How is propofol distributed in the body?

Propofol is rapidly and extensively distributed in the body. It crosses the blood-brain barrier quickly, and its short duration of action is due to rapid redistribution from the CNS to other tissues, high metabolic clearance and high lipophilicity. MICROMEDEX Thomson Health Care.