What does C FMS stand for?
Macrophage colony-stimulating factor receptor c-fms is a novel target of imatinib.
Where is CSF1R located?
The CSF1R gene provides instructions for making a protein called the colony stimulating factor 1 receptor (CSF-1 receptor). This protein is found in the outer membrane of certain cell types.
How does a colony stimulating factors work?
Colony-stimulating factors (CSFs) are secreted glycoproteins that bind to receptor proteins on the surfaces of hematopoietic stem cells, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate into a specific kind of blood cell, usually white blood cells.
What is CSF1R gene?
Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation 115), is a cell-surface protein encoded, in humans, by the CSF1R gene (known also as c-FMS). It is a receptor for a cytokine called colony stimulating factor 1.
What are cytokines and colony stimulating factors CSF )?
CSF3, also known as Granulocyte Colony Stimulating Factor (G-CSF) is a glycoprotein which stimulates bone marrow to produce granulocytes and stem cells and then to release them into the blood stream.
What is G-CSF used for?
G-CSF is used in patients who have certain cancers and neutropenia caused by some types of chemotherapy and in patients who have severe chronic neutropenia that is not caused by cancer treatment. It is also used before an autologous stem cell transplant. G-CSF helps the bone marrow make more white blood cells.
What are interleukins and colony stimulating factors?
Multiple-Colony-Stimulating Factors or Interleukin 3 IL-3 stimulates bone marrow stem cells to differentiate into myeloid progenitor cells. It also stimulates the proliferation of mature granulocytes, monocytes, and dendritic cells.
How does granulocyte colony-stimulating factor work?
Granulocyte colony-stimulating factor (G-CSF) is a blood growth factor (special proteins produced by the body) that stimulates the bone marrow to produce more infection-fighting white blood cells called neutrophils. Granulocyte colony-stimulating factor causes cells from the bone marrow to become mature and activated.
What is granulocyte colony stimulating factor used for?
Granulocyte colony-stimulating factor is used in patients who have certain cancers and neutropenia caused by some types of chemotherapy and in patients who have severe chronic neutropenia that is not caused by cancer treatment. It is also used before an autologous stem cell transplant.
What does GM-CSF stimulate?
Granulocyte macrophage colony-stimulating factor (GM-CSF) is a cytokine that promotes myeloid cell development and maturation, and dendritic cell differentiation and survival in vitro.
What is the function of interleukins?
The primary function of interleukins is, therefore, to modulate growth, differentiation, and activation during inflammatory and immune responses. Interleukins consist of a large group of proteins that can elicit many reactions in cells and tissues by binding to high-affinity receptors in cell surfaces.
Where is granulocyte colony-stimulating factor?
Granulocyte colony-stimulating factor is injected into the fatty portion of the skin, usually in the upper arm, thigh, or abdomen. To avoid infection, you should wash your hands before and after the injection and clean the injection site. Each needle should be used only once and disposed of properly.
What is the function of CSF1R receptor?
Function. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSF1R through a process of oligomerization and trans-phosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/ PDGF receptor family of tyrosine-protein kinases.
Why do v-fms transform cells that do not have CSF-1 receptors?
The genetic alterations in the c-fms gene that unmask its latent transforming potential abrogate its lineage-specific activity and enable v-fms to transform a variety of cells that do not normally express CSF-1 receptors. Publication types Research Support, Non-U.S. Gov’t
What is c-fms (CSF1R)?
c-FMS (CSF1R, CSF-1R) is located at the cell plasma membrane. c-FMS is the receptor for the ligand colony stimulating factor-1 (CSF1).
What is the function of c-fms?
c-FMS is the receptor for the ligand colony stimulating factor-1 (CSF1). c-FMS is an integral transmembrane glycoprotein that exhibits ligand-induced tyrosine-specific protein kinase activity, which triggers a signaling cascade eventually affecting transcription of CSF1-responsive genes.