What does TSLP stand for?
About TSLP: TSLP stands for Thymic Stromal Lymphopoietin. It is a cytokine protein often linked to T Cell maturation and antigen presenting cells.
How is TSLP produced?
TSLP is produced by a range of cells, including epithelial cells, fibroblasts, stromal cells, and keratinocytes. DCs are important primary targets of TSLP, and we now unexpectedly demonstrate that DCs also produce TSLP in response to Toll-like receptor (TLR) stimulation and that this is augmented by IL-4.
Where is TSLP found?
The functional TSLPR is mainly expressed in hematopoietic cells (dendritic cells [DC], T cells, B cells, natural killer (NK) cells, iNKT, monocytes, basophils, mast cells and eosinophils), liver, brain, skeletal muscle, kidney, spleen and thymus [50,57–59]. The human TSLP gene is located on chromosome 5q22.
Who discovered TSLP?
Vassili Soumelis and Yong-Jun Liu bring us back to the discovery and functional characterization of human TSLP, in the very stimulating environment of the DNAX Research Institute. The 1980s and 1990s were the golden years for the discovery of cytokines by academic institutions and biotech companies1.
Is TSLP a cytokine?
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a murine thymic stromal cell line. TSLP exerts its biological effects by binding to a high-affinity heteromeric complex composed of thymic stromal lymphopoietin receptor chain and IL-7Rα.
Is TSLP an Alarmin?
Furthermore, alarmin cytokines such as TSLP, IL-33, and IL-25 may act on other inflammatory and structural cells within the airway mucosa, which contribute to the airway inflammation and associated structural changes, such as fibrosis and neoangiogenesis, observed in the airways of patients with asthma (3–9).
When was TSLP discovered?
Thymic stromal lymphopoietin (TSLP) is a member of the IL-2 cytokine family, and a distant paralog of IL-7 (Leonard, 2002). Murine TSLP was discovered in thymic stromal cell line supernatants that supported B cell development (Friend et al., 1994).
What is TSLP asthma?
Thymic stromal lymphopoietin (TSLP) is an allarmin cytokine whose importance in human asthma has been repeatedly documented. Accordingly, targeting of TSLP and TSLP-mediated signalling is considered as an attractive therapeutic strategy to asthma.
What is the function of the TSLP gene?
TSLP synergized with CD40 ligand to promote dendritic cell activation and pathogenic IL-23 production by primary blood and skin dendritic cells. It plays an important role as a master switch of allergic inflammation because it promotes Th2-type immune responses by inducing the activation of dendritic cells.
What is TSLP inflammation?
Thymic stromal lymphopoietin (TSLP) is a critical upstream cytokine inducing type 2 inflammation in various diseases, including asthma and atopic dermatitis.
What is Tslp asthma?
What is Tslp inflammation?
Who produce interleukins?
The majority of interleukins are synthesized by CD4 helper T-lymphocyte, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T and B lymphocytes, and hematopoietic cells.
Are interferons and interleukins the same?
Interferons are glycoproteins produced by a wide variety of cells in response to infection. Interleukins are a group of cytokines that play crucial roles in proliferation, activation, maturation, and differentiation of immune cells.