What is ambrisentan generic for?
The US Food and Drug Administration (FDA) has approved four generic versions of Gilead Sciences’ Letairis (ambrisentan), an endothelin receptor antagonist indicated for treatment for pulmonary arterial hypertension (PAH).
How quickly does ambrisentan work?
How long does it take for ambrisentan (Letairis) to work? Most people will start to notice better exercise ability after taking ambrisentan (Letairis) for one month. It can take up to three months to notice the full effects of this medication.
Is ambrisentan a specialty drug?
Gilead Sciences, a biopharmaceutical firm based in Foster City, Calif., has chosen eight specialty pharmacies to distribute Letairis (ambrisentan), a drug that treats a potentially deadly form of pulmonary high blood pressure.
How do I get ambrisentan?
Females can only receive Letairis through a restricted program called the Letairis Risk Evaluation and Mitigation (REMS) program. If you are a female who can get pregnant, you must talk to your doctor, understand the benefits and risks of Letairis, and agree to all of the instructions in the Letairis REMS program.
How effective is ambrisentan?
Ambrisentan (average daily dose of 6.27 mg) significantly improved exercise capacity (6MWD) from baseline (mean: 377.1 m [m]) at week 12 (+53.6 m, p < 0.001) (primary endpoint). Improvement in exercise capacity was noted as early as week 4, and was sustained up to week 24 (+ 64.4 m, p < 0.001).
What happens if I stop taking ambrisentan?
Do not stop taking ambrisentan without talking to your doctor. If you suddenly stop taking ambrisentan, your condition may worsen.
What are side effects of ambrisentan?
Common side effects of Letairis include:
- stuffy nose,
- runny nose,
- sinus pain,
- headache,
- abdominal or stomach pain,
- vomiting,
- constipation,
- sore throat, or.
What happens if you stop taking ambrisentan?
Does ambrisentan lower BP?
Ambrisentan (Oral) Ambrisentan lowers blood pressure in your lungs, helping your heart pump blood more efficiently. Ambrisentan is used to treat pulmonary arterial hypertension (PAH) in adults. It improves your ability to exercise and prevents your condition from getting worse.
Does ambrisentan cause anemia?
Results from the VOLT post-marketing program confirmed the safety profile of ambrisentan observed in the ARIES studies, including the low incidence of liver function test abnormalities. Peripheral edema and anemia were common side effects of endothelin receptor antagonist therapies, including ambrisentan.
Does ambrisentan cause weight gain?
Many people using this medication do not have serious side effects. Tell your doctor immediately if any of these unlikely but serious side effects occur: fast heartbeat, extreme tiredness, swelling ankles/feet, sudden/unexplained weight gain, trouble breathing.