What is chronic Villitis?
Chronic villitis is the classic chronic inflammatory lesion of the placenta characterized by the presence of chronic inflammatory cells infiltrating the chorionic villi leading to villous agglutination and ultimately loss of placental function.
What causes Villitis?
Villitis is inflammation of the chorionic villi, which are the structures covering the surface of the placenta that ensure the baby receives enough nutrients and gases from the mother. This inflammation can stem from chorioamnionitis or other infectious agents such as Streptococci, herpes, rubella and syphilis.
What causes chronic Deciduitis?
Chronic deciduitis is thought to result from chronic inflammation of the maternal genital tract or an abnormal immune response to the placenta. Increased decidual lymphocytes are seen, and the most rigorous definitions require the presence of plasma cells .
How common is chronic Villitis?
Villitis of unknown etiology (VUE) is an important pattern of placental injury occurring predominantly in term placentas. Although overlapping with infectious villitis, its clinical and histologic characteristics are distinct. It is a common lesion, affecting 5% to 15% of all placentas.
What does acute villitis mean?
Acute villitis is an uncommon histological pattern which involves neutrophil infiltration of the chorionic villi beneath the trophoblastic membrane, and can occur with or without chorioamnionitis (28) (Figure 3).
What does Deciduitis mean?
inflammation of the decidua
Medical Definition of deciduitis : inflammation of the decidua.
What does acute Villitis mean?
What is chronic chorioamnionitis?
Chronic chorioamnionitis is defined by the infiltration of lymphocytes in the chorioamniotic membranes and the chorionic plate, similar to that of neutrophils in acute chorioamnionitis. 21. The original description and characterization of this lesion represents a series of seminal contributions.
What causes inflammation in the placenta?
Abstract. Chronic inflammatory lesions of the placenta are characterized by the infiltration of the organ by lymphocytes, plasma cells, and/or macrophages and may result from infections (viral, bacterial, parasitic) or be of immune origin (maternal anti-fetal rejection).
What is multifocal chronic Villitis?
Low grade chronic villitis can be either focal or multifocal. Focal has involved villi on only one glass slide, while multifocal has involved villi on at least two slides. High grade chronic villitis has more than 10 inflamed villi per focus. High grade chronic villitis is differentiated into diffuse and patchy.
Is chorioamnionitis serious?
Chorioamnionitis can cause a dangerous blood infection in the mother called bacteremia. This can cause the baby to be born early. It can also cause serious complications in the newborn. This includes infection (such as pneumonia or meningitis), brain damage, or death.
What are the signs and symptoms of chorioamnionitis?
Chorioamnionitis is an infection of the placenta and the amniotic fluid. It happens more often when the amniotic sac is broken for a long time before birth. The major symptom is fever. Other symptoms include a fast heart rate, sore or painful uterus, and amniotic fluid that smells bad.
How do you know if your placenta is infected?
What causes inflammation in placenta?
What causes a placenta to become infected?
The most common cause is bacteria moving up through the vagina and cervix. It can also come through the maternal blood stream through the placenta. Infection may also be a complication of invasive procedures such as amniocentesis or fetoscopy.
How do you treat an infected placenta?
How is chorioamnionitis treated? If your doctor diagnoses chorioamnionitis, he or she may treat you with antibiotics to help treat the infection. However, often the treatment is to deliver the fetus. If the newborn has an infection, he or she will be given antibiotics as well.