What is Il in structure?
In structure, IL-10 is a protein of about 160 amino acids that contains four conserved cysteines involved in disulphide bonds.
What are IL-12 and IL-23?
IL-23 belongs to the IL-12 family, it is composed of one subunit of p40, that is shared with IL12, and one subunit of p19, which is unique[31]. IL-23 is produced by myeloid DCs or conventional DCs and macrophages in response to bacterial stimulation, endogenous signals or CD40L activation[32,33].
What is Th17?
What are T helper 17 (Th17) cells? CD4+ T helper lymphocytes are mediators of cellular immunity that play a critical role in the activation of other immune cells such as B cells and cytotoxic T cells, as well as in the regulation of immune responses.
Is IL 22 anti-inflammatory?
IL-22 is a pro- and anti-inflammatory cytokine that is mainly produced by T cells and NK cells. Recent studies have reported the increased number of IL-22 producing T cells in patients with autoimmune noninfectious uveitis; however, the correlation between IL-22 and uveitis remains unclear.
Are interleukins antibodies?
Interleukins are a diverse, multifunctional group of proteins that carry out communication between various immune cells and control their gene expression. They manage the intensity and magnitude of an inflammatory response, and control differentiation, proliferation, and secretion of antibodies.
Is IL-2 proinflammatory?
Both proinflammatory (IL2, IL6, IFNgamma, TNFalpha) and anti-inflammatory (IL4, IL10) cytokines were significantly increased in infected infants compared with non-infected infants.
What type of cytokine is IL-2?
Interleukin-2 (IL-2) is a pleiotropic cytokine that drives T-cell growth, augments NK cytolytic activity, induces the differentiation of regulatory T cells, and mediates activation-induced cell death.
What cytokines do Th17 cells produce?
Th17 cells produce the cytokines IL-17A [IL-17] (1–2) and IL-17F (5), as well as the cytokines IL-21 (6–7) and IL-22 (8–9).