What is raloxifene hydrochloride used for?
A drug used to reduce the risk of invasive breast cancer in postmenopausal women who are at high risk of developing the disease or who have osteoporosis and to prevent and treat osteoporosis in postmenopausal women.
Does raloxifene increase testosterone?
Results: Raloxifene significantly increased serum concentrations of LH and FSH (by 29% and 21%), total testosterone (20%), free testosterone (16%) and bioavailable testosterone (not bound to sex hormone-binding globulin (SHBG; 20%). In parallel with testosterone, 17 beta-oestradiol also increased by 21%.
What is the mechanism of action of raloxifene?
The mechanism of action of raloxifene occurs through binding to estrogen receptors. This binding results in activation of estrogenic pathways (estrogen-agonistic effect) and blockade (estrogen-antagonistic effect) in tissues that express estrogen receptors.
What are side effects of raloxifene?
Raloxifene may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- hot flashes (more common in the first 6 months of raloxifene therapy)
- leg cramps.
- swelling of the hands, feet, ankles, or lower legs.
- flu-like syndrome.
- joint pain.
- sweating.
- difficulty falling asleep or staying asleep.
Does raloxifene have side effects?
Seek immediate medical attention if any of these unlikely but serious side effects occur: leg swelling/pain, trouble breathing, chest pain, sudden vision changes, severe headache, weakness on one side of the body, confusion. A very serious allergic reaction to this drug is rare.
Does raloxifene make you gain weight?
Raloxifene is associated with significantly less vaginal discharge and severe hot flashes than tamoxifen in women with early breast cancer. Although weight gain of >10 pounds may also occur less frequently on this drug, this may be confounded by the shorter average duration of raloxifene therapy.
What are the side effects of taking raloxifene?
Who should not use raloxifene?
38 Do not take EVISTA if you: 39 • have or have had blood clots in your legs, lungs, or eyes. Taking EVISTA may increas 40 the risk of getting blood clots. e 41 • are pregnant or could become pregnant. EVISTA could harm your unborn child.
What time of day should you take raloxifene?
You can take raloxifene at whatever time of day you find easiest to remember but try to take your doses at the same time of day, each day. This will help you to remember to take your doses regularly. You can take the tablet either before or after a meal. If you forget to take a dose, take it as soon as you remember.
Who should not take raloxifene?
What is the best time of day to take raloxifene?
How many years can you take raloxifene?
Abstract. Background: Due to the chronic nature of osteoporosis and the risk of invasive breast cancer, raloxifene 60 mg/day (raloxifene) is intended to be used for long-term treatment (treatment >3 years).
Can you take raloxifene for 20 years?
Background: Due to the chronic nature of osteoporosis and the risk of invasive breast cancer, raloxifene 60 mg/day (raloxifene) is intended to be used for long-term treatment (treatment >3 years).
Is raloxifene safe long-term?
Raloxifene is associated with an increased risk of deep vein thrombosis, pulmonary embolism, and retinal vein thrombosis. An increased risk of death due to stroke was observed in a trial in postmenopausal women with documented coronary heart disease or at increased risk for major coronary events.