When do you start antiplatelet after TIA?
Antiplatelet therapy should be started as soon as possible after brain imaging has excluded hemorrhage, within 24 hours of symptom onset (ideally within 12 hours) [Evidence Level B].
Which antiplatelet is contraindicated in patient with history of TIA?
Prasugrel is contraindicated in patients with a history of stroke or TIA because of the increased risk of significant or fatal bleeding, which was established in the 2007 TRITON-TIMI-38 trial comparing dual antiplatelet therapy of prasugrel/aspirin with clopidogrel/asirin in more than 13,000 patients.
What medication is first line therapy for TIAS?
Antiplatelet agents, rather than oral anticoagulants, are recommended as initial therapy. Aspirin 50–325 mg/day, a combination of aspirin and extended-release dipyridamole, and clopidogrel are all reasonable first-line options (class I recommendation).
When do you start clopidogrel after a TIA?
Recent minor non-cardioembolic ischemic stroke or high-risk TIA, DAPT with aspirin plus clopidogrel should be initiated early (ideally within 12–24 hours of symptom onset and at least within 7 days of onset) and continued for 21–90 days.
When do you stop clopidogrel after a TIA?
Although it was recommended that clopidogrel be stopped after 30 days, some patients continued clopidogrel in addition to aspirin (deliberately or inadvertently) for longer before stopping.
Is clopidogrel good for TIA?
What is Clopidogrel? Clopidogrel is a type of medicine called an antiplatelet: it reduces the risk of blood clots forming within your circulatory system or blood vessels. Taking this medication can reduce your risk of having a stroke or Transient Ischaemic Attack (TIA) which is also sometimes called a mini stroke.
Which antiplatelet drug’s is are first line choice when patients present with acute ischemic stroke?
Antiplatelet Therapy Aspirin continues to be the drug of choice for the antiplatelet treatment of AIS, with administration required within 24 to 48 hours after onset of stroke symptoms. However, the guidelines emphasize that aspirin alone is not a substitute for mechanical thrombectomy or IV alteplase if indicated.
How long should I take clopidogrel after a TIA?
Aspirin plus clopidogrel for 21 to 30 days after TIA or minor stroke reduces recurrent stroke. Aspirin plus clopidogrel is more effective than aspirin but less effective than anticoagulation for preventing stroke from atrial fibrillation.
Is aspirin recommended after a TIA?
Aspirin is recommended for secondary prevention after transient ischaemic attack (TIA) or ischaemic stroke on the basis of trials showing a 13% reduction in long-term risk of recurrent stroke.
Is aspirin indicated after TIA?
How long should you take clopidogrel after a TIA?
Based on the results of the CHANCE trial, the American Heart Association/American Stroke Association recommends clopidogrel and aspirin for 21 days starting in the first 24 hours after a minor stroke or TIA.
When do you start clopidogrel after stroke?
What antiplatelet regimen would you recommend for the secondary prevention of acute ischemic stroke?
Regarding antiplatelet therapy, the guidelines recommend the use of aspirin 50 mg to 325 mg daily (class I recommendation), aspirin/ER-DP 25 mg/200 mg twice daily (class I), or clopidogrel 75 mg daily (class IIb).
Why is clopidogrel preferred over aspirin?
Clopidogrel is another guideline‐recommended antiplatelet agent21 and has been shown to be superior to aspirin in preventing composite vascular events and reducing hemorrhagic complications in a randomized controlled trial, CAPRIE (Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events).
How long should I take clopidogrel after a stroke?
How long should you be on clopidogrel after a TIA?
What is the role of anti-platelet therapy in the treatment of Tia?
All patients with ischemic stroke or transient ischemic attack (TIA) should be prescribed anti-platelet therapy for secondary prevention of recurrent stroke. All patients with ischemic stroke or transient ischemic attack (TIA) should be prescribed anti-platelet therapy for secondary prevention of recurrent stroke.
What is the best anti-platelet therapy for stroke patients?
Anti-platelet Therapy in Ischemic Stroke and TIA. Acetylsalicylic acid (80 mg – 325 mg), combined acetylsalicylic acid (25 mg) and extended-release dipyridamole (200 mg), or clopidogrel (75 mg) are all appropriate options and selection should depend on the clinical circumstances [Evidence Level A].
What is the best dual antiplatelet treatment for platelet disorders?
(NEW FOR 2020): Another reasonable short-term dual antiplatelet treatment option is the combination of daily low-dose acetylsalicylic acid plus ticagrelor (180 mg loading dose, followed by 90 mg bid) for 30 days.
Is ticagrelor an option for dual antiplatelet therapy with aspirin?
Now, results from a recent study published in NEJM suggest that ticagrelor could be another option for dual antiplatelet therapy with aspirin.