Which amino acid side chain resembles the imidazole ring?
Among the proteinogenic amino acids, histidine plays manifold roles mostly ascribable to the reactivity of the imidazole ring that characterizes its side chain.
Is imidazole an amine?
Imidazole: An aromatic amine of molecular formula C3H4N2 having the molecular structure shown below, or a molecule containing this moiety.
Which drugs are imidazole?
Many imidazole-based derivatives have been marketed as antifungal drugs such as ketoconazole (1), miconazole (2), clotrimazole (3), tioconazole (4), econazole (5), tinidazole (6), enilconazole/imazalil (7), parconazole (8), eberconazole (9), lanoconazole (10), fenticonazole (11), bifonazole (12), sulconazole (13).
Which drug contains imidazole nucleus?
There are different examples of commercially available drugs in the market which contains 1, 3-diazole ring such as clemizole (antihistaminic agent), etonitazene (analgesic), enviroxime (antiviral), astemizole (antihistaminic agent), omeprazole, pantoprazole (antiulcer), thiabendazole (antihelmintic), nocodazole ( …
Which amino acid contains an imidazole group?
Histidine
Histidine, an essential amino acid, has as a positively charged imidazole functional group. The imidazole makes it a common participant in enzyme catalyzed reactions.
Which amino acid has an imidazole group?
Is imidazole aromatic amine?
What drug class is imidazole?
Imidazoles belong to the class of azole antifungals, which includes ketoconazole, miconazole, and clotrimazole. For comparison, another group of azoles is the triazoles, which includes fluconazole, itraconazole, and voriconazole.
Is fluconazole an imidazole?
Antifungal imidazoles Potential interactions of zolpidem with three commonly prescribed azole derivatives (ketoconazole, itraconazole, and fluconazole) have been evaluated in a controlled clinical study.
Is clotrimazole an imidazole?
Clotrimazole, an imidazole antimycotic, interferes with the rise in cytosolic Ca2+ and inhibits cell proliferation in a reversible manner. Here we describe the effect of clotrimazole on vascular endothelial cells (ECs).
Which of the following amino acids contain an imidazole moiety?
Five amino acids contribute to this type. The side chains are positively charged; they are lysine, which has a butylammonium side chain, arginine, which has a guanidine group, and histidine, which bears an imidazolium moiety.
Which amino acids are similar to each other?
According to Grantham’s distance, most similar amino acids are leucine and isoleucine and the most distant are cysteine and tryptophan.
What is the difference between L histidine and histidine?
L-histidine is the L-enantiomer of the amino acid histidine. It has a role as a nutraceutical, a micronutrient, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a human metabolite, an algal metabolite and a mouse metabolite. It is a proteinogenic amino acid, a histidine and a L-alpha-amino acid.
What is imidazole functional group?
Imidazole is an organic compound with the formula C3N2H4. It is a white or colourless solid that is soluble in water, producing a mildly alkaline solution. In chemistry, it is an aromatic heterocycle, classified as a diazole, and has non-adjacent nitrogen atoms.
What is azole group?
Azoles are a class of five-membered heterocyclic compounds containing a nitrogen atom and at least one other non-carbon atom (i.e. nitrogen, sulfur, or oxygen) as part of the ring. Their names originate from the Hantzsch–Widman nomenclature.
What are R groups in amino acids?
Each of the 20 amino acids has a specific side chain, known as an R group, that is also attached to the α carbon. The R groups have a variety of shapes, sizes, charges, and reactivities. This allows amino acids to be grouped according to the chemical properties of their side chains.
Are cysteine and serine similar?
Cysteine differs from serine in a single atom– the sulfur of the thiol replaces the oxygen of the alcohol. The amino acids are, however, much more different in their physical and chemical properties than their similarity might suggest.
Are serine and alanine similar?
Serine differs from alanine in that one of the methylenic hydrogens is replaced by a hydroxyl group. Serine is one of two hydroxyl amino acids. Both are commonly considered to by hydrophilic due to the hydrogen bonding capacity of the hydroxyl group.
What is imidazole?
Imidazole is an organic compound with the formula C 3 N 2 H 4. It is a white or colourless solid that is soluble in water, producing a mildly alkaline solution. In chemistry, it is an aromatic heterocycle, classified as a diazole, and has non-adjacent nitrogen atoms. Many natural products, especially alkaloids, contain the imidazole ring.
Which of the following drugs contains an imidazole ring?
This ring system is present in important biological building blocks, such as histidine and the related hormone histamine. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.
What are some examples of imidazole derivatives?
These imidazole derivatives are known to exhibit an extensive range of biological activities. Metronidazole, clotrimazole, esomeprazole, clonidines are few examples of the commercially available drugs with imidazole ring ( 53–56, Fig. 13.5) [66].
What is a substitute for imidazole?
A number of substituted imidazoles, including clotrimazole, are selective inhibitors of nitric oxide synthase, which makes them interesting drug targets in inflammation, neurodegenerative diseases and tumors of the nervous system.