Why streptokinase is given within 12 hours?
Thus, ‘accelerated’ streptokinase given over 15 minutes in patients presenting within 12 hours of acute myocardial infarction is well tolerated and results in higher grades of TIMI flow in the infarct-related artery as compared to the “conventional” one-hour infusion regimen.
How do you prepare a streptokinase injection?
The preparation is administered intravenously in the initial dose of 250000 IU in 50 ml of isotonic solution of sodium chloride during 30 minutes (30 drops per minute). This dose usually induces the beginning of thrombosis lysis. After that the administration of streptokinase in the dose of 100000 IU per hour follows.
What can you do for streptokinase?
Streptokinase is used to dissolve blood clots that have formed in the blood vessels. It is used immediately after symptoms of a heart attack occur to improve patient survival. This medicine may also be used to treat blood clots in the lungs (pulmonary embolism) and in the legs (deep venous thrombosis) .
Why is streptokinase no longer used?
Medical uses As streptokinase is a bacterial product, the body has the ability to build up an immunity to it. Therefore, it is recommended that this medication should not be used again after four days from the first administration, as it may not be as effective and can also cause an allergic reaction.
What are the precautions before streptokinase can be given?
What are the warnings and precautions for Streptokinase? Caution should be exercised in patients with history of vision problems due to diabetes, bleeding disorders, high blood pressure, infection in heart valves, recent biopsy or surgery, recent injury, any allergy and elderly.
How streptokinase is diluted?
When diluting the 1,500,000 IU infusion bottle (50 mL), slowly add 5 mL Sodium Chloride Injection, USP, or 5% Dextrose Injection, USP, directing it at the side of the bottle rather than into the drug powder. Roll and tilt the bottle gently to reconstitute. Avoid shaking as it may cause foaming.
How do you reteplase an injection?
Reteplase should be administered via an IV line in which no other medication is being simultaneously injected or infused. Do not add any other medications to the injection solution.
Can streptokinase be given twice?
The report also says that streptokinase should not be given twice because of the formation of anti-streptokinase antibodies. We found that almost all patients had low titres of anti-streptokinase antibodies before thrombolysis; they increased rapidly after treatment but then started to fall.
What are the disadvantages of streptokinase?
The most problematic is its anticoagulant effect lasting more than 24 hours after its administration and simultaneous increase in prothrombotic activity, which is a disadvantage if intervention treatment methods are appropriate (direct coronary angioplasty).
How do I give STK?
Answer. The adult dose of streptokinase for AMI is 1.5 million U in 50 mL of 5% dextrose in water (D5W) given IV over 60 minutes. Allergic reactions force the termination of many infusions before a therapeutic dose can be administered.
What is the most important complication of streptokinase therapy?
The hemorrhagic stroke as the most serious ADR of streptokinase was documented in three patients.
Why can you not give tPA after 4 hours?
Most of them are ineligible because they come to the hospital after the three-hour time window.” The timing of treatment is important, because giving a strong blood thinner like tPA during a stroke can cause bleeding inside the brain.
What is Retefast kit?
Retefast Kit is a medicine that dissolves clots that have formed in blood vessels. It is used to treat a heart attack. It is known as a thrombolytic or “clot-busting” drug. This medicine restores the blood flow to the affected tissue, thereby preventing tissue death.
When should reteplase be given?
Usual Adult Dose for Myocardial Infarction 10 units administered over 2 minutes as an IV bolus as soon as possible after the onset of acute myocardial infarction (AMI) symptoms, followed 30 minutes later by a second 10 unit IV bolus injection also administered over 2 minutes.
Which is the antidote for streptokinase?
Drugs that can reverse effects of streptokinase include aminocaproic acid, aprotinin, and tranexamic acid.
What’s the antidote of streptokinase?