Can you take Cipro and theophylline together?
Interactions between your drugs Ciprofloxacin may significantly increase the blood levels of theophylline, which may lead to potentially serious and life-threatening side effects. Talk to your doctor if you have any questions or concerns.
What impact or consequence should ciprofloxacin administration have on the pharmacologic response to theophylline?
Concomitant administration of ciprofloxacin with theophylline decreases the clearance of theophylline resulting in elevated serum theophylline levels and increased risk of a patient developing CNS or other adverse reactions.
Is it safe for dogs to take ciprofloxacin?
Ciprofloxacin generic tablets approved for human use frequently are administered to dogs for treatment of bacterial infections because they are inexpensive and readily available.
What are the side effects of ciprofloxacin in dogs?
Side effects of this medication include gastrointestinal distress (vomiting, anorexia, esophagitis [inflammation or irritation of the esophagus – the tube connecting the mouth and stomach], and diarrhea), cloudy urine, nervousness, agitation, anxiety, difficulty sleeping, and allergic or hypersensitivity reactions.
What drugs interact with theophylline?
TABLE II. Clinically significant drug interactions with theophylline.*
| Drug | Type of Interaction |
|---|---|
| Carbamazepine | Similar to aminoglutethimide. |
| Cimetidine | Decreases theophylline clearance by inhibiting cytochrome P450 1A2. |
| Ciprofloxacin | Similar to cimetidine. |
| Clarithromycin | Similar to erythromycin. |
What is the risk of using quinolones theophylline combination?
The authors reviewed 48 reports of adverse events that occurred when ciprofloxacin or norfloxacin was prescribed in conjunction with theophylline. About a third of the patients had seizures, and many others had central nervous system side effects such as agitation, confusion, nausea, and vomiting.
How much ciprofloxacin can I give my dog?
The usual dose of ciprofloxacin for dogs and cats is 2.27-6.8 mg/lb every 12 hours. Always follow the dosage instructions provided by your veterinarian. The usual dose of ciprofloxacin for dogs and cats is 2.27-6.8 mg/lb every 12 hours.
Which medications can increase the risk of theophylline toxicity?
Causes of chronic theophylline toxicity include the following: Drug interactions (eg, ethanol [ETOH], cimetidine, oral contraceptives, allopurinol, macrolide antibiotics, quinolone antibiotics)
What are the side effects of theophylline for dogs?
The most common side effects include central nervous system stimulation (excitement) and stomach or intestinal irritation such as nausea, vomiting, and diarrhea. Other side effects include sleeplessness, increased drinking, eating, and urinating.
What drugs interact with fluoroquinolones?
Fluoroquinolones, especially enoxacin, and to a lesser extent ciprofloxacin and pefloxacin, inhibit the metabolic clearance of theophylline and caffeine. It is advisable to use non-interacting quinolones such as ofloxacin or norfloxacin or to measure theophylline levels and reduce caffeine intake where appropriate.
Which antibiotic can elevated theophylline levels?
Administration of allopurinol, oral contraceptives, cimetidine, erythromycin, quinolone antibiotics, fluvoxamine, zileuton, and zafirlukast has been shown to increase theophylline levels.
How long should a dog take theophylline?
The dosage and administration of Theophylline varies according to the size and breed of the pet being treated, and the type and severity of their illness, but typically, the drug is taken every 6, 8, 12, or 24 hours.
How long does it take theophylline to work in a dog?
1 to 2 days
This medication should take effect within 1 to 2 days, and you should see improvements in your pet’s clinical signs.
What should fluoroquinolones not be taken with?
The oral absorption of all fluoroquinolones is significantly impaired when coadministered with aluminum- and magnesium-containing antacids and sucralfate, as well as with other metal cations such as calcium and iron. Concomitant use of these agents, even when dosed several hours apart, should be avoided.