Does HIV cause lipodystrophy?

Does HIV cause lipodystrophy?

Key Points. Lipodystrophy refers to the changes in body fat that can affect some people with HIV. Lipodystrophy can include buildup of body fat, loss of body fat, or both. Lipodystrophy may be due to HIV infection or medicines used to treat HIV, but its actual cause is not understood.

How common is lipodystrophy in HIV?

The exact prevalence of HIV-associated lipodystrophy has been challenging to establish due to differences in case definition, but estimates range from 10% to 80% among all people living with HIV worldwide. [6] The newer HIV medicines are thought to be less likely to cause lipodystrophy than the previously used agents.

Does HIV cause metabolic syndrome?

People with HIV infection have metabolic abnormalities that resemble metabolic syndrome (hypertriglyceridemia, low high-density lipoprotein cholesterol, and insulin resistance), which is known to predict increased risk of cardiovascular disease (CVD).

Does HIV affect fat cells?

Subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) alterations are often observed among people living with HIV. Some insults to adipose tissue could result from HIV infection.

What causes progressive lipodystrophy?

Lipodystrophy may be genetic or acquired. Genetic types are present from birth, while acquired types develop later in life. There are several types of acquired lipodystrophy, and each may have a different cause. Possible causes include viral infections, autoimmune diseases, and the use of certain medications.

Is lipodystrophy an autoimmune disease?

Acquired lipodystrophies do not have a direct genetic cause, but rather many different factors may be involved. Acquired lipodystrophies can be caused by medications, autoimmunity or for unknown reasons (idiopathic).

Is lipodystrophy fatal?

A person can be born with lipodystrophy or develop it later in life. In either case, the resulting inability to maintain fat tissue beneath the skin can have severe, life-threatening consequences over time.

Is lipodystrophy serious?

Lipodystrophy is a progressive condition that can cause serious complications, including : multi-organ damage. fatty deposits in the liver. kidney damage.

What is the prognosis of HIV-associated lipodystrophy?

The prognosis of HIV-Associated Lipodystrophy depends upon many factors including the duration of HIV and ART, health condition of the individual, and severity of the signs and symptoms among other factors Who gets HIV-Associated Lipodystrophy? (Age and Sex Distribution)

Which HIV drugs cause lipodystrophy?

Symptoms. There are two types of lipodystrophy: fat loss and fat buildup.

  • Causes. Older kinds of drugs to treat HIV like stavudine (d4T,Zerit ),zidovudine (AZT,Retrovir ),and some of the older protease inhibitors,like indinavir (Crixivan) have been linked
  • Getting a Diagnosis. A physical exam may be enough.
  • Treatment.

    • How to diagnose a lipodystrophy syndrome?

    Severe weight loss due to anorexia nervosa,starvation,malnutrition,uncontrolled diabetes,hyperthyroidism,adrenal insufficiency,cancer cachexia,or severe chronic infection.

  • Donohue syndrome (leprechaunism) and Rabson–Mendenhall syndrome,which are both recessive syndromes associated to variants in the INSRgene.
  • Multiple symmetric lipomatosis.

    • Why is HIV virus called syndrome?

    It was called Syndrome , because it attacks the immune system of the body and so the person not fight against the disease and the person suffers from many small disease. Since AIDS is a collection of disease, hence its called as Syndrome not disease.